{"product_id":"target-gb-x™","title":"Target gb-X 30 Sachets by Klaire Labs","description":"\u003cp\u003eA targeted probiotic blend clinically demonstrated to support mood†\u003cbr\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003eTarget gb-X is a probiotic supplement specifically designed to support positive mood by influencing the gut-brain axis through the microbiome.\u003c\/p\u003e\n\u003cp\u003eIt is powered by Ecologic BARRIER, a 5B CFU blend of 9 probiotic strains, that has been clinically shown to decrease overall cognitive reactivity to sad mood, rumination, negative thoughts, and aggressive thoughts.\u003c\/p\u003e\n\u003cp\u003eHeightened cognitive reactivity to sad mood is an established risk factor for more serious mood alterations in otherwise healthy individuals, and is therefore considered an important target for interventions.\u003c\/p\u003e\n\u003cp\u003eTarget gb-X Mechanism\u003c\/p\u003e\n\u003cp\u003eTarget gb-X with Ecologic BARRIER was specifically designed to influence the gut-brain axis through defined mechanisms including strengthening of the gut barrier function, modulation of cytokines and inflammatory response, production of potentially neuroprotective metabolites, and HPA regulation. Preclinical research emphasized a pronounced shift away from macrophage-produced cytokines to T-lymphocyte-produced cytokines, a reduction in circulating lipopolysaccharide endotoxins, and a marked reduction in transcription of hippocampal genes related to HPA regulation.2\u003c\/p\u003e\n\u003cp\u003eProbiotics and the Gut-Brain Axis\u003c\/p\u003e\n\u003cp\u003eThe gut-brain axis refers to the bidirectional communication network between the central and autonomic nervous systems and the intestines. Gut-brain communications are mediated by the immune system, endocrine connections such as the hypothalamic-pituitary-adrenal (HPA) axis, and neural pathways involving the enteric nervous system.\u003c\/p\u003e\n\u003cp\u003eThe gut microbiota is now known to play a pivotal role in gut-brain communications. It is a complex interaction whereas the microbiota engages locally with intestinal cells as well as communicating directly with the central nervous system through neuroendocrine, immune, and metabolic pathways.3 Research into gut-brain mechanisms is rapidly expanding our understanding and serves to inform the development of targeted probiotic formulations.\u003c\/p\u003e","brand":"Klaire Labs","offers":[{"title":"Default Title","offer_id":19233051377721,"sku":"K10081","price":45.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0021\/0019\/9481\/products\/gbx.png?v=1756322485","url":"https:\/\/living-well-today-international.myshopify.com\/products\/target-gb-x%e2%84%a2","provider":"Living Well Today International","version":"1.0","type":"link"}